Johnson & Johnson single-shot COVID-19 vaccine demonstrated a durable immune response and elicited dual mechanisms of protection against delta and other SARS-CoV-2 variants in data published in NEJM

Written by | 3 Aug 2021 | COVID-19

Interim results from a Phase 1/IIa sub-study published in the New England Journal of Medicine (NEJM) demonstrated that both humoral (antibody) and cellular (T-cell) immune responses generated by the Johnson & Johnson single-shot COVID-19 vaccine (JNJ 78436735) were strong and stable through eight months after immunization, the length of time evaluated to date. Data showed that T-cell responses – including the important CD8+ T-cells that seek out and destroy infected cells – persisted over the eight-month timeframe examined. Data from the study, conducted in collaboration with Dan Barouch, M.D., Ph.D., et al. of Beth Israel Deaconess Medical Center, suggest maturation of B-cell response without further boosting. Mature B-cells produce antibodies, which can help fight the virus that causes COVID-19.

Findings indicate that a single dose of the Johnson & Johnson COVID-19 vaccine elicited dual mechanisms of protection against COVID-19 disease, including against disease caused by the Delta variant (B.1.617.2) and other SARS-CoV-2 variants of concern, including the Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Epsilon (B.1.429) and Kappa (B.1.617.1) variants, as well as the original SARS-CoV-2 strain (WA1/2020). These data suggest an expansion of neutralizing antibodies over eight months, along with the observations of durable T-cell responses and the suggestion of B-cell maturation.

See-“Durable Humoral and Cellular Immune Responses 8 Months after Ad26.COV2.S Vaccination”-July 14, 2021.Dan H. Barouch, M.D., Ph.D. DOI: 10.1056/NEJMc2108829.

Newsletter Icon

Sign up to our mailing list

If you're a healthcare professional you can sign up to our mailing list to receive high quality medical, pharmaceutical and healthcare news and e-journals. Get the latest news and information across a broad range of specialities delivered straight to your inbox.

Sign Up

You can unsubscribe at any time using the 'Unsubscribe' link at the bottom of all our email journals and publications.